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HistaFlex und Anticholinerge Wirkungen

Das Überprüfungsergebnis der Interaktion von Arzneimittel HistaFlex und Krankheit Anticholinerge Wirkungen auf Sicherheit bei der gemeinsamen Nutzung.

Ergebnis der Prüfung:

HistaFlex <> Anticholinerge Wirkungen

Relevanz: 23.07.2019 Rezensent: Dr.med. Shkutko P.M., in

Bei der Überprüfung der Interaktion aus seriösen Quellen Drugs.com, Rxlist.com, Webmd.com, Medscape.com wurden Kontraindikationen oder Nebenwirkungen festgestellt, die Schäden verursachen oder die negativen Auswirkungen bei der Verwendung des Arzneimittels bei dieser Begleiterkrankung zu verstärken.

Konsument:

Antihistaminika oft haben anticholinerge Aktivität auf, die ältere Patienten sind besonders empfindlich. Die Therapie mit Antihistaminika gegeben werden sollte vorsichtig, wenn überhaupt, bei Patienten mit vorbestehenden Erkrankungen, die wahrscheinlich noch verschärft werden durch die anticholinerge Aktivität, wie Harnverhalt oder Verstopfung; Engwinkelglaukom, unbehandelte intraokulare Hypertonie, oder unkontrollierte primäre Offenwinkelglaukom; und Magen-Darm-obstruktive Erkrankungen. Konventionelle, first-generation antihistamine wie die Ethanolamine (bromodiphenhydramine, carbinoxamine, Clemastin, dimenhydrinate, Diphenhydramin, doxylamine, phenyltoloxamine) dazu neigen, weisen erhebliche anticholinerge Effekte. Im Gegensatz dazu, ist die neuere, relativ nonsedating Antihistaminika (z.B. Cetirizin, Fexofenadin, Loratadin) haben angeblich niedrige minimale anticholinerge Aktivität auf, die normalerweise empfohlenen Dosierungen und können geeignete alternativen.

Quellenmaterial

"Product Information. Optimine (azatadine)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Periactin (cyproheptadine)." Merck & Co, Inc, West Point, PA.
"Product Information. Drixoral (dextromethorphan)." Schering-Plough, Liberty Corner, NJ.
"Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
"Product Information. Semprex-D (acrivastine-pseudoephedrine)." Endo Laboratories LLC, Chadds Ford, PA.
"Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.
Watemberg NM, Roth KS, Alehan FK, Epstein CE "Central anticholinergic syndrome on therapeutic doses of cyproheptadine." Pediatrics 103 (1999): 158-60
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
"Product Information. Vistaril (hydroxyzine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
"Product Information. Chlortrimeton (chlorpheniramine)." Schering-Plough, Liberty Corner, NJ.
"Product Information. Tacaryl (methdilazine)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Antivert (meclizine)." Roerig Division, New York, NY.
"Product Information. Temaril (trimeprazine)" Allergan Inc, Irvine, CA.
"Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmaceutical Company, St. Louis, MO.

HistaFlex

Generischer Name: acetaminophen / pyrilamine

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Synonyme: nein

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