Suche des Arzneimittels anhand seiner Bezeichnung

HistaFlex und Nieren- / Lebererkrankung

Das Überprüfungsergebnis der Interaktion von Arzneimittel HistaFlex und Krankheit Nieren- / Lebererkrankung auf Sicherheit bei der gemeinsamen Nutzung.

Ergebnis der Prüfung:

HistaFlex <> Nieren- / Lebererkrankung

Relevanz: 23.07.2019 Rezensent: Dr.med. Shkutko P.M., in

Bei der Überprüfung der Interaktion aus seriösen Quellen Drugs.com, Rxlist.com, Webmd.com, Medscape.com wurden Kontraindikationen oder Nebenwirkungen festgestellt, die Schäden verursachen oder die negativen Auswirkungen bei der Verwendung des Arzneimittels bei dieser Begleiterkrankung zu verstärken.

Konsument:

Begrenzte pharmakokinetische Daten sind verfügbar für die älteren, der ersten generation der Antihistaminika. Viele erscheinen werden primär durch die Leber metabolisiert, und beide Eltern Drogen und Metaboliten werden in den Urin ausgeschieden. Patienten mit Nieren und/oder Leber-Krankheit kann ein erhöhtes Risiko für schädliche Wirkungen von Antihistaminika aufgrund von Drogen-und Metaboliten-Akkumulation. Die Therapie mit Antihistaminika verabreicht werden soll vorsichtig bei solchen Patienten. Niedrigere anfängliche Dosen angebracht sein.

Quellenmaterial

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Simons FE, Frith EM, Simons KJ "The pharmacokinetics and antihistaminic effects of brompheniramine." J Allergy Clin Immunol 70 (1982): 458-64
Bruce RB, Turnbull LB, Newman JH, Pitts JE "Metabolism of brompheniramine." J Med Chem 11 (1968): 1031-4
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Maddox DE, Reed CE "Clinical pharmacodynamics of antihistamines." Ann Allergy 59 (1987): 43-8
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Simons FE, Watson WT, Chen XY, Minuk GY, Simons KJ "The pharmacokinetics and pharmacodynamics of hydroxyzine in patients with primary biliary cirrhosis." J Clin Pharmacol 29 (1989): 809-15
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Huang SM, Athanikar NK, Sridhar K, Huang YC, Chiou WL "Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults." Eur J Clin Pharmacol 22 (1982): 359-65

HistaFlex

Generischer Name: acetaminophen / pyrilamine

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Synonyme: nein

Was ist HistaFlex?